Comparison of Amplicor and GeneXpert MTB/RIF for Diagnosis of Tuberculous Meningitis

There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert MTB/RIF tests were similar: 46 (31–60) versus 50 (33–67) and 99 (93–100) and 94 (84–99), respectively.

Authors: 
Vinod B. Patel, Cathy Connolly, Ravesh Singh, Laura Lenders, Brian Matinyenya, Grant Theron, Thumbi Ndung'u, Keertan Dheda
Journal: 
Journal of Clinical Microbiology
Volume: 
52
Issue: 
10
Publication Date: 
October, 2014
IBN number: 
10.1128/JCM.01235-14